Riboflavin/UVA cross-linking is a technique introduced in the past decades for the treatment of keratoconus, keratectasia, and\ninfectious keratitis. Its efficacy and safety have been investigatedwith clinical and laboratory studies since its first clinical application\nby Wollensak for the treatment of keratoconus. Although its complications are encountered during clinical practice, such as\ninfection inducing risk, minimal invasion merits a further investigation on its future application in clinical practice. Recently,\ncollagen cross-linking in sclera shows a promising prospect. In present study, we summarized the representative studies describing\nthe clinical and laboratory application of collagen cross-linking published in past decades and provided our opinion on the positive\nand negative results of cross-linking in the treatment of ophthalmic disorders.
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